Prof. Mario Galgani, PhD. (male) is a Professor of General Pathology and Immunology at “Federico II” University of Naples, School of Medicine, Department of Molecular Medicine and Medical Biotechnology and a Research Associate at the National Research Council (CNR) - Naples, Italy. Prof. Galgani is the co-Director of the Immunogenetics of Transplants Laboratory - Azienda Universitaria Policlinico “Federico II” – Napoli, Italy. Prof. Galgani’s research group continues to work on the cellular and molecular pathological mechanisms on the basis of loss of immunological self-tolerance, and the subsequent development of autoimmune disorders, including type 1 diabetes (T1D), Coeliac disease (CD) and Multiple Sclerosis (MS). We are working on several broad areas, including dissecting the biological processes responsible for the numeric and functional defects of regulatory T cell populations in autoimmune diseases. Prof. Galgani’s work has been widely recognized by several prestigious original publications (77 papers published, H-Index 31, citations 2.838) in top journals and invitations to international meetings. Contribution to the project: Our laboratory will be involved in the INITIALISE by assessing the impact of various early-life exposures and microbially-derived metabolites on cellular immune determinates involved in the control of immunological self-tolerance and progression of autoimmune disorders (WP6). In particular, our group will analyze the frequency, phenotype and functional capability of different subsets of regulatory T lymphocytes, including canonical FoxP3+ and recently identified TR3-56 cells.